Het ras de Ierse Wolfshond heeft last van diverse erfelijke afwijkingen, maar voor niet een van deze afwijkingen is een DNA test beschikbaar. Vandaar dat ik die nog nooit aangevraagd had voor Gaia. Met de keuze voor een Oud Duitse Herder als reu vond ik het wel belangrijk om te testen op DM (Degeneratieve Myelopathie). Vader Eron is vrij dus er kan sowieso geen lijder geboren worden, maar voor de toekomst is het wel belangrijk om te weten of er dragers geboren kunnen worden. De keuze is op Embark gevallen omdat W.O.L.F., World of Lupine Foundation, hier ook mee werkt en wellicht gaat deze F1 generatie in de toekomst wat betekenen voor het ras Lupine.

Een samenvatting van de resultaten:

Health:
Carrier for 1 genetic condition, Canine Multifocal Retinopathy Cmr3 (BEST1 Exon 10 SNP), recessief
Clear Love me Im Irish v. Krolewna Smieszka is clear of all (164) the other Clinical conditions that Embark tests for.

Genetic Diversity:
Inbreeding Coefficient: 42%. Helaas kan Embark mij niet goed uitleggen hoe ze dat uit haar DNA kunnen halen.

MHC Class II – DLA DRB1: No Diversity (29% van de honden hebben No diversity, 10% Low diversity en 61% High diversity.
A Dog Leukocyte Antigen (DLA) gene, DRB1 encodes a major histocompatibility complex (MHC) protein involved in the immune response. Some studies have shown associations between certain DRB1 haplotypes and autoimmune diseases such as Cushing’s disease, but these findings have yet to be scientifically validated.

MHC Class II – DLA DQA1 and DQB1: No Diversity (29% van de honden hebben No diversity, 7% Low diversity en 64% High diversity.
DQA1 and DQB1 are two tightly linked DLA genes that code for MHC proteins involved in the immune response. A number of studies have shown correlations of DQA-DQB1 haplotypes and certain autoimmune diseases; however, these have not yet been scientifically validated.

Ancestry:
Irish Wolfhound. Geen verrassing 😉

Haplogroup: A1e
This female lineage likely stems from some of the original Central Asian wolves that were domesticated into modern dogs starting about 15,000 years ago. It seemed to be a fairly rare dog line for most of dog history until the past 300 years, when the lineage seemed to “explode” out and spread quickly. What really separates this group from the pack is its presence in Alaskan village dogs and Samoyeds. It is possible that this was an indigenous lineage brought to the Americas from Siberia when people were first starting to make that trip themselves! We see this lineage pop up in overwhelming numbers of Irish Wolfhounds, and it also occurs frequently in popular large breeds like Bernese Mountain Dogs, Saint Bernards and Great Danes. Shetland Sheepdogs are also common members of this maternal line, and we see it a lot in Boxers, too. Though it may be all mixed up with European dogs thanks to recent breeding events, its origins in the Americas makes it a very exciting lineage for sure!

Haplotype: A25
Part of the large A1e haplogroup, we have detected this haplotype in village dogs in Mexico. We also see it in Irish Wolfhounds, Great Pyrenees, Brittanys, and Labrador Retrievers.